Metabolic basis to Sherpa altitude adaptation


Nepalese Sherpas have a physiology that uses oxygen more efficiently than those used to the atmosphere at sea level. The biochemical tests on the fresh muscle showed that the Sherpas’ tissue was able to make much better use of oxygen by limiting the amount of body fat burned (i.e. low levels of fatty acid oxidation)…

Visualize & cluster one-mode projection of a bi-partite graph


A lot of genomic knowledge are often curated in the form of genesets where a combination of genes are involved in certain biological process/function/pathway. In other words, a pathway is often enriched with different combination of genes. Similarly this can also be related to patient-genesets data structure. This can be thought of as a bipartite…

Lecture Series on – “Conservation Biology and Wildlife Genetics in Nepal”


8 lecture series on the theme “Conservation Biology and Wildlife Genetics in Nepal” was held at Kathmandu University. The lecture series was given by Prof Dr Jacques Van Alphen (University of Amsterdam) and Dr Laura Bertola (Leiden University) and was jointly organized by Himalayan Tiger Foundations and Center for Molecular Dynamics Nepal (CMDN). (24-25 Nov…

Genetic Ancestry of Nepalis


One evening, few years back, my grandpa passed down a legacy to me and my cousins – the story of our ancestors. I belong to a Newar community which is one among the indigenous people of Kathmandu Valley. Newars have been living in Kathmandu valley from the prehistoric times. As per my grandpa, our ancestors…

Bioinformatics for personal genome interpretation


Following paper is a very good review on the the current bioinformatics methods applied in Personalize Genomics and the challenges to understand the biological data. Capriotti E, Nehrt NL, Kann MG, Bromberg Y. Bioinformatics for personal genome interpretation.Brief Bioinform. 2012 Jan 13. Abstract: An international consortium released the first draft sequence of the human genome…